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Chemical peels using glycolic or lactic acid at professional concentrations accelerate pigmented cell turnover, laser treatments like Q-switched or IPL target melanin directly with high energy, dermal fillers restore volume correcting structural shadows peptides cannot address, and microneedling enhances peptide penetration while stimulating additional collagen production through controlled injury response

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185 Once ECs are damaged, various pathophysiological changes, such as thrombosis, inflammation, and excessive proliferation of smooth muscle cells, will be induced